MHC-II deficiency among Egyptians: novel mutations and unique phenotypes
ConclusionGiven that Egypt is a North African country with a high rate of consanguinity, MHC-II deficiency is not rare. However, the molecular defects differ from those reported in nearby countries. Early diagnosis must be based upon suspicious clinical signs and laboratory diagnosis since the defect can be missed by T cell receptor excision circles based neonatal screening.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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