New urine dipstick test detects cause of disease that blinds millions
(Scripps Research Institute) Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.
ConclusionThe culture system we have established forO.volvulus young adult worms offers a promising new platform to advance drug discovery against the human filarial parasite,O.volvulus and thus supports the continuous pursuit for effective macrofilaricidal drugs. However, thisin vitro culturing system will have to be further validated for reproducibility before it can be rolled out as a drug screen for decision making in macrofilaricide drug development programs.
Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite ...
The new data could help identify treatments for diseases ranging from river blindness to schistosomiasis.
ConclusionKeen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.
Conclusions/SignificanceWe report for the first time the anti-onchocercal activities of these locally consumed medicinal plants and lantadene A, a potential lead for further development as an onchocerciasis cure.
Conclusions/SignificanceWHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection.
Customized iPhones are just one example of devices that can be used to combat health threats in developing countries. They are helping scientists in California and Cameroon attack the parasite that causes river blindness, an African scourge.Kaiser Health News
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Onchocerciasis is a chronic parasitic infection originally endemic in 13 discrete regional foci distributed among six countries of Latin America (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela). In...
ConclusionsA specific concern is the burden of disease caused by onchocerciasis-associated epilepsy in hyperendemic zones situated in countries experiencing difficulties in strengthening their onchocerciasis control programmes. These difficulties should be identified and programmes supported during the transition from morbidity control to interruption of transmission and elimination.