Effectiveness of pneumococcal Haemophilus influenzae protein D conjugate vaccine against pneumonia in children: A cluster-randomised trial.

Effectiveness of pneumococcal Haemophilus influenzae protein D conjugate vaccine against pneumonia in children: A cluster-randomised trial. Vaccine. 2018 Aug 22;: Authors: Kilpi TM, Jokinen J, Puumalainen T, Nieminen H, Ruokokoski E, Rinta-Kokko H, Traskine M, Lommel P, Moreira M, Ruiz-Guinazu J, Borys D, Schuerman L, Palmu AA Abstract BACKGROUND: Pneumococcal conjugate vaccines have potential to prevent significant proportion of childhood pneumonia. Finnish Invasive Pneumococcal disease vaccine trial was designed to assess the vaccine effectiveness (VE) of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against several outcomes. We now report results for pneumonia. METHODS: In this nationwide, cluster-randomised, double-blind trial, children younger than 19 months received PHiD-CV10 in 52 clusters or hepatitis vaccines as control in 26 clusters. Infants younger than 7 months at the first vaccination received either 3+1 or 2+1 vaccination schedule, children aged 7-11 months received 2+1, and those 12-18 months of age two-dose schedule. All hospitalizations and outpatient visits to hospital associated with ICD-10 codes compatible with pneumonia were identified through the National Care Register and 1-3 frontal chest X-ray images per event were collected. External readers who were unaware of the patients' vaccination status retrospectively interpreted the images. The evaluated outcomes were hospital-di...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

Related Links:

Should hepatitis C-infected kidneys be transplanted into uninfected recipients as standard practice? This editorial explores the issues.American Journal of Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news
ConclusionsGlecaprevir/pibrentasvir was highly efficacious and well tolerated in HCV treatment-na ïve patients with APRI ≤ 1 and no prior evidence of cirrhosis.Trial RegistrationClinicalTrials.gov number, NCT03212521.FundingAbbVie.Plain Language SummaryPlain language summary available for this article.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
(Elsevier) A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions. The drug also decreased existing precancerous lesions. If proven effective clinically, MPA may be a boon to women who do not have access to human papillomavirus (HPV) vaccines.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract Objective: To characterize the behavior of cardiac autonomic modulation in individuals with different times after orthotopic heart transplantation (HTx) using symbolic dynamics analysis. Methods: Sixty patients were evaluated after HTx. We recorded their instantaneous R-R intervals (RRi) by cardiac monitor Polar ® RS800CX ™ (Polar Electro Oy, Kempele, Finland) for 10 minutes. The same sequence of RRi with 256 consecutive beats was used to perform spectral analysis and symbolic dynamics analysis. We used hierarchical clustering to form groups. One-way analysis of variance (ANOVA) (with Holm-Sidak method) ...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 10 November 2019Source: Veterinary ParasitologyAuthor(s): Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima RafatiAbstractCutaneous leishmaniosis (CL) is a parasitic disease in animals and human with no satisfactory treatments and vaccination. Rapamycin is a potent inhibitor of mammalian target of rapamycin (mTOR) with various applications. Here, the effect of rapamycin alone or in combination with two other drugs, namely amphotericin B (AmB) and glucantime, was investigated against Leishmania tropica infection. In...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
New wart treatment involves injecting the measles, mumps and rubella (MMR) vaccine into warts which could banish the skin growths for good. The patients would receive four doses of it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In conclusion, it seems essential to implement effective educational and informative activities targeted to parents to reinforce positive attitudes toward vaccinations. PMID: 31705322 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Emergency admissions have risen more than 50 per cent over the last decade, with 56,000 British children hospitalised with the condition last year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Pneumonia killed more than 800,000 babies and young children last year - or one child every 39 seconds - despite being curable and mostly preventable, global health agencies said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This study investigates how unemployment is associated with the transition to parenthood among men and women in times of increased instability in the labour market. We provide novel insights into how education and life stage might modify the link between unemployment and fertility. We focus on a Nordic welfare state, Finland, and apply event history models to a rich register sample covering the years 1988–2009 (N = 306,413). We find that unemployment or a weaker labour market attachment tends to delay parenthood among both men and women, but the association is stronger for men. In most groups, the accum...
Source: Advances in Life Course Research - Category: Reproduction Medicine Source Type: research
More News: Allergy & Immunology | Children | Clinical Trials | Finland Health | Haemophilus Influenzae (Hib) | Hepatitis | Hepatitis Vaccine | Influenza Vaccine | Meningitis Vaccine | Otitis | Otitis Media | Pneomococcal Vaccine | Pneumonia | Vaccines