Drug reduces deaths and hospitalizations from underdiagnosed form of heart failure

(Columbia University Irving Medical Center) A study led by Columbia University cardiologist Mathew Maurer showed that tafamidis reduced deaths from a type of heart failure called transthyretin amyloid cardiomyopathy. The drug could be one of the first effective treatments for the disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 23 March 2019Source: Revista Portuguesa de Cardiologia (English Edition)Author(s): Maria Emanuel Amaral, Pedro Epifânio, Natália Noronha, António Pires, Paula Martins, Vanda Azevedo, Eduardo Castela, Manuel J. AntunesAbstractAnomalous origin of the left coronary artery from the pulmonary artery is a rare congenital heart defect and a cause of myocardial ischemia during childhood. Most undiagnosed cases die in the first year of life as an extensive collateral network is essential for survival. The diagnosis requires a high index of clinical suspicion. The authors presen...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
We report a case of a 29-year old male with HF, dilated cardiomyopathy possibly related to myocarditis, and atrial fibrillation with reduced ejection fraction. Sacubitril/valsartan treatment was initiated after two years of standard treatment. In two years, therapy with sacubitril/valsartan led to persistence in sinus rhythm and progressive recovery of ejection fraction, functionality, and reduction of cardiac volumes. The patient is currently in good condition and has suspended diuretic therapy in the last six months. PMID: 30895821 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Severini D, Mboumi K Abstract Sacubitril/valsartan was shown to be effective in improving the clinical outcome and reducing hospitalization rate and mortality in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). Here we report a case series of three patients with HFrEF associated with mitral insufficiency (case #1), dilated cardiomyopathy (case #2), and chronic ischaemia (case #3). The first case was a 49-year-old male and the further two were 70-year-old male patients. After previous ineffective treatment, the administration of sacubitril/valsartan led to a rapid and...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusion and perspectivesOur studies will allow us to determine the importance of glucose uptake and usage in the failing adult heart.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionSMIT1 expression is increased in ischemic failing heart, reflecting increased cardiac fibrosis. The physiological and physiopathological role of SMIT1 in the heart remains to be determined.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionSERCA stimulation can be considered a promising therapeutic approach for diastolic dysfunction treatment.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: April 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 2Author(s): M. Samia el Hayek, P. Gerbaud, C. Valdivia, S. Gomez, F. Lefebvre, J. Chen, H. Valdivia, J.P. Benitah, A.M. Gomez, L. PereiraIntroductionEpidemiological and preclinical studies have pointed out a correlation between hyperglycemia and increasing risk of heart failure and cardiac death. In cardiomyocytes, hyperglycemia has been shown to alter Ca2 +  signalling via CaMKII. Yet, the underlying mechanisms are still unclear.ObjectiveTo determine the molecular basis of high glucose-mediated Ca2 +  ...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionThis work highlights the role of FLNCin studied cardiomyopathy subtypes. A correlation between the type of the mutation and the cardiomyopathy subtype was observed as well as with SCD risk. These new data should be taken into consideration for patient's management and primary prevention of sudden cardiac death.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
The efficacy of cell transplantation in heart failure is reportedly modest, but adjuvant drugs combined with cell therapy may improve this efficacy. Peroxisome proliferator-activated receptor (PPAR) γ, one of t...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
We report a case of PPCM that was triggered by postpartum thyroiditis. Despite the presence of myocardial damage indicated by cardiac magnetic resonance imaging, the patient’s cardiac function completely recovered with the addition of bromocriptine to standard therapies. We discuss the role of thyroid hormones in the development of PPCM through aggravation of a prolactin-dependent anti-angiogenic effect, and we argue that more attention should be paid to postpartum thyroiditis as a novel risk factor for PPCM.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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