Cirrhotic stiffness affects the migration of hepatocellular carcinoma cells and induces sorafenib resistance through YAP

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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Publication date: Available online 19 June 2019Source: Chemico-Biological InteractionsAuthor(s): Yeonhwa Song, I-Seul Park, Jiho Kim, Inhee Choi, Haeng Ran SeoAbstractLiver cancer is one of the most frequently occurring types of cancer with high mortality rate. Hepatocellular carcinoma (HCC) frequently metastasizes to lung, portal vein, and portal lymph nodes and most HCCs show strong resistance to conventional anticancer drugs. Cancer stem cells (CSCs) are considered to be responsible for resistance to therapies. Hence, recent advancements in the use of liver cancer stem cells (LCSCs) are rapidly gaining recognition as an...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 19 June 2019Source: Genes &DiseasesAuthor(s): Wei Wang, Bo Hu, Jiang-Jiang Qin, Jianwen Cheng, Xin Li, Mehrdad Rajaei, Jia Fan, Xin-Rong Yang, Ruiwen ZhangAbstractOverexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma (HCC) and are associated with increased mortality due to this disease. Inhibiting MDM2 has been demonstrated to be a valid approach for the treatment of HCC. However, most of the MDM2 inhibitors evaluated to date have been designed to block the MDM2 and p53 binding, and have limited efficacy against tumors...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 18 June 2019Source: European Journal of RadiologyAuthor(s): He-qing Wang, Chun Yang, Meng-su Zeng, Sheng-xiang Rao, Yuan Ji, Xin Weng, Ji-yong Wang, Ruo-fan ShengAbstractPurposeTo investigate potential findings associated with cytokeratin 19 (CK19)-positive HCC, with special emphasis on MR texture analysis.Materials and methodsForty-eight patients with CK19-negative HCC and 38 patients with CK19-positive were retrospectively evaluated by texture analysis based on conventional MRI. Clinicalpathological characteristics, conventional MR imaging findings, and the MR texture analysis contained...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conditions:   Hepatocellular Carcinoma;   Postoperative Infection Interventions:   Drug: postoperative antimicrobial prophylaxis;   Other: No postoperative antimicrobial prophylaxis Sponsor:   Sun Yat-sen University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Liver and Intrahepatic Bile Duct Carcinoma Interventions:   Radiation: Computed Tomography Perfusion Imaging;   Procedure: Liver Biopsy Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Recruiting
Source: - Category: Research Source Type: clinical trials
SHANGHAI, June 19, 2019 -- (Healthcare Sales &Marketing Network) -- CARsgen Therapeutics, a clinical-stage company committed to developing Chimeric Antigen Receptor T cell therapies for cancer, today announced that one of its leading drug candidates, CT0... Biopharmaceuticals, Oncology, FDA CARsgen Therapeutics, T cell, CAR-T, hepatocellular carcinoma
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Conclusions: Although HCC occurrence after DAAs was not high, recurrence was apparently high. Pretreatment alpha-fetoprotein is a predictor for de novo HCC. The time between HCC ablation and DAAs was the strongest predictor of recurrence.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Abstract The quantification of low concentration proteins can facilitate the discovery of some significant biomarkers, and provide us a more profound understanding of cell heterogeneity when applied to single cell analysis. However, most state-of- art single cell protein detection platforms are bulky, expensive and complicated. Here we report a simple and low cost microfluidic dPCR (digital polymerase chain reaction) chip-based proximity ligation assay (PLA) for the quantification of low concentration proteins. First, standard hCSTB (human cystatin B) protein was used to optimize the related experimental condition...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Contrast-enhanced ultrasound can distinguish ductal carcinoma in situ (DCIS)...Read more on AuntMinnie.comRelated Reading: Ultrasound options abound for diagnosing liver disease ICUS applauds payment changes for CEUS Contrast ultrasound helps characterize breast lesions Drop ultrasound contrast agent warning, society says Contrast US tops CT, MRI for classifying kidney tumors
Source: Headlines - Category: Radiology Source Type: news
Contributors : Qin Li ; HeMing Zhou ; JiGang ZhangSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensTranscriptional profiling of human hepatoellular carcinoma (HCC) cell line: MHCC-97H comparing control untreated MHCC-97H cells with MHCC-97H cells overexpressed ROCK1 protein. Goal was to determine the effect of ROCK1 on global MHCC-97H cell mRNA and lncRNA expression.Transcriptional profiling of human hepatoellular carcinoma (HCC) cell line: MHCC-97H comparing control untreated MHCC-97H cells with MHCC-97H cells overexpressed ROCK2 protein. Goal was to determine the effec...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research
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