brain neurokinin-1 receptor availability in never-medicated patients with major depression – a pilot study

Neurotransmitter substance P (SP) acts as general neuromodulator that maintains brain homeostasis and regulates stress responses, emesis, pain, mood, and anxiety. The majority of these actions are transmitted via the neurokinin-1 receptor (NK1R) subtype that has also emerged as a target for treatment of affective disorders (Chandra et al., 2010; Gobbi and Blier, 2005; Hesketh et al., 2003; Kramer et al., 1998; McCabe et al., 2009; Rupniak et al., 2000; Santarelli et al., 2001; Teixeira et al., 2004).

Source: Journal of Affective Disorders - August 25, 2018 Category: Neurology Authors: Mikko Nyman, Olli Eskola, Jaana Kajander, Riitta Jokinen, Jukka Penttinen, Tomi Karjalainen, Lauri Nummenmaa, Jussi Hirvonen, Donald Burns, Richard Hargreaves, Olof Solin, Jarmo Hietala Tags: Research paper Source Type: research