Stem cell cure hope for Crohn’s disease

THOUSANDS of patients with untreatable Crohn ’s disease could now be cured with an infusion of their own stem cells, experts believe. And they say the pioneering technique, which has had success in preliminary trials, could be applied to other devastating immune disorders such as rheumatoid arthritis and multiple sclerosis.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Kristina Kuhbandner1, Anna Hammer1, Stefanie Haase1, Elisa Terbrack1, Alana Hoffmann2, Angela Schippers3, Norbert Wagner3, Rehana Z. Hussain4, William A. Miller-Little4, Andrew Y. Koh5, Joshua S. Stoolman6, Benjamin M. Segal6, Ralf A. Linker7† and Olaf Stüve4,8*† 1Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany 2Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany 3Department of Pediatrics, University Hospital RWTH Aachen, Aachen, Germany 4...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Noymar Luque-Campos1, Rafael A. Contreras-López1, María Jose Paredes-Martínez1, Maria Jose Torres2, Sarah Bahraoui3, Mingxing Wei4, Francisco Espinoza5, Farida Djouad3*, Roberto Javier Elizondo-Vega6* and Patricia Luz-Crawford1* 1Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile 2Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile 3IRMB, INSERM, Univ Montpellier, Montpellier, France 4Cellvax, SAS...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: This article reviews cytokine involvement in alloimmunity and the potential role cytokine-targeted therapy may play in prevention of allograft rejection in solid organ transplant recipients. PMID: 30562564 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
CONCLUSIONThis study confirms that the morbidity and mortality of ASCT for patients with autoimmune disease is similar to that for other patient groups undergoing ASCT. Patient selection should take this into consideration.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 731. Clinical Autologous Transplantation: Results: Poster III Source Type: research
Publication date: November 2018Source: Autoimmunity Reviews, Volume 17, Issue 11Author(s): Kassem Sharif, Howard Amital, Yehuda ShoenfeldAbstractAutoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is essential...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 11 September 2018Source: Autoimmunity ReviewsAuthor(s): Kassem Sharif, Howard Amital, Yehuda Shoenfeld, MaACRAbstractAutoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is es...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Autoimmune diseases commonly affect women of childbearing age, yet the risk of adverse pregnancy outcomes among women with autoimmune disease is underexamined. We hypothesized pregnancies complicated by Type 1 diabetes mellitus (T1DM), systemic lupus erythematosus (SLE) Crohn ’s disease, multiple sclerosis (MS) or rheumatoid arthritis (RA) would have increased risk of preeclampsia, preterm birth (PTB), small for gestational age (SGA), respiratory distress syndrome (RDS), and neonatal intensive care (NICU) admission.
Source: Annals of Epidemiology - Category: Epidemiology Authors: Source Type: research
Abstract Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses, but also in the development and maintenance of immune tolerance. Numerous protocols have been developed to generate tolerogenic DCs (tolDCs) ex vivo, and the therapeutic efficacy of ex vivo-generated tolDCs has been demonstrated in autoimmune disease animal models. Based on successes in small animal models, several clinical trials have been completed or are on-going in patients with autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and Crohn's disease. Here we describe the met...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
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