Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice.

Conclusion: Our study demonstrates for the first time that diacerein improves renal function efficiently in endotoxemic AKI mice by suppressing inflammation and altering tubular water and sodium handing. These results suggest that diacerein may be a novel therapeutic agent for the treatment of endotoxemic AKI.
PMID: 30140293 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Yu G, Liu Q, Dong X, Tang K, Li B, Liu C, Zhang W, Wang Y, Jin Y Tags: Cell Mol Biol Lett Source Type: research