Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element.

Conclusion: Our results indicate that Oct4 is involved in DNA methylation through the regulation of Dnmt1 transcription, especially during the early stages of mouse pre-implantation embryo development.
PMID: 30140294 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - August 25, 2018 Category: Biochemistry Authors: Wu F, Wu Q, Li D, Zhang Y, Wang R, Liu Y, Li W Tags: Cell Mol Biol Lett Source Type: research