Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy.

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy. Acta Med Okayama. 2018 Aug;72(4):401-406 Authors: Wada N, Ikeda F, Mori C, Takaguchi K, Fujioka SI, Kobashi H, Morimoto Y, Kariyama K, Sakaguchi K, Hashimoto N, Moriya A, Kawaguchi M, Miyatake H, Hagihara H, Kubota J, Takayama H, Takeuchi Y, Yasunaka T, Takaki A, Iwasaki Y, Okada H Abstract Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR ...
Source: Acta Medica Okayama - Category: General Medicine Tags: Acta Med Okayama Source Type: research