Serine/threonine kinase 31 promotes PDCD5 ‐mediated apoptosis in p53‐dependent human colon cancer cells

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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Conclusions Collectively, there is consistent, compelling evidence that physical activity plays a role in preventing many types of cancer and for improving longevity among cancer survivors, although the evidence related to higher risk of melanoma demonstrates the importance of sun safe practices while being physically active. Together, these findings underscore the importance of physical activity in cancer prevention and control. Fitness and public health professionals and health care providers worldwide are encouraged to spread the message to the general population and cancer survivors to be physically active as their a...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: SPECIAL COMMUNICATIONS Source Type: research
ConclusionsSporadic dMMR breast cancers are extremely rare (Davies et al. in Cancer Res 77:4755 –4762, 2017). It seems reasonable to conclude that identifying a dMMR breast cancer in a patient with known LS strongly suggests that her LS is breast cancer-predisposing. LS patients with dMMR breast cancers might therefore be considered for above-average breast cancer screening for the developme nt of additional breast cancers. Also, the FDA recently granted approval of checkpoint inhibitor therapy for all metastatic dMMR solid malignancies (Lemery et al. in N Engl J Med 377:1409–1412, 2017). MMR expression assays ...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionRACRS is safe in the treatment of patients with stage I –III colorectal cancer. Oncological outcome did not differ between RACRS and LCRS groups. RACRS had lower conversion and intra-operative complication rates.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionThe fusion fascia of Fredet is useful to achieve CME and D3-L in right colon cancers with reduced risk of intraoperative complications. This structure is particularly suitable for minimally invasive surgery; therefore, we encourage awareness of the fascia of Fredet by colorectal surgeons.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Conclusions: We suggested that GB polyps are associated with proximal colon polyps. Colonoscopy may be a more effective strategy for screening proximal precancerous lesions among patients with GB polyps. The association between GB disease and colon polyps demands further prospective investigation. PMID: 31611916 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
AbstractBackgroundThe incidence in young patients has increased significantly over the last few decades. The aim of this study is to evaluate demographic and tumor characteristics of young patients and analyze the short-term surgical outcomes of patients undergoing surgery.MethodsWe performed a 2-year review (2015 –2016) of the ACS-NSQIP and included all patients with CC who underwent surgical management. Patients were stratified into two groups: early-onset CC (
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Dominique Guenot Advanced colorectal cancer has a poor prognosis because of metastasis formation and resistance to combined therapies. Downstream of PI3K/Akt and Ras/MAPK pathways, the mTOR kinase plays a decisive role in treatment failure. We previously established that irinotecan has antiangiogenic properties and it is known that new mammalian target of rapamycin (mTOR) catalytic AZD inhibitors, unlike rapamycin, target both mTORC1 and mTORC2. Thus, we hypothesized that the complete inhibition of the PI3K/AKT/mTOR/HIF-1α axis with mTOR catalytic inhibitors and low doses of irinotecan may have antitumor ef...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Promising accuracy of colon capsule endoscopy (CCE-2) has been shown for overall neoplasia. Advanced neoplasia (AN) represents the main target of colorectal cancer screening programs. Our aim was to assess CCE-2 diagnostic accuracy for the detection of AN in FIT+ screenees.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Source Type: research
We report the first case of a patient with colon cancer who was diagnosed with a thyroid metastasis in a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). A 55-year-old male patient presented with a 19  mm thyroid nodule in the inferior left lobe. It was EU-TIRADS 5 on echography and suspicious of papillary thyroid carcinoma (Bethesda V) on cytology. Macroscopically, the nodule was fleshy and completely encapsulated. At frozen section examination, it demonstrated follicular architecture with mild atypia. Inside the nodule was a focus of tumor with glandular architecture, marked cell...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
(Natural News) Researchers from the U.S. have found that vitamin D can potentially be used in cancer treatment. In their findings, which they published in the journal JAMA, revealed that supplementing vitamin D can inhibit the progression of advanced colorectal cancer. What is colorectal cancer? Colorectal cancer is the term for cancers that develop in the colon...
Source: - Category: Consumer Health News Source Type: news
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