Gastrin ‐releasing peptide receptor gene silencing inhibits the development of the epithelial–mesenchymal transition and formation of a calcium oxalate crystal in renal tubular epithelial cells in mice with kidney stones via the PI3K/Akt signaling pathway

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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In recent years, work has been done to understand the mechanisms of Doppler ultrasound twinkling artifacts (TAs) and why they appear over kidney stones. In the work described here, twinkling artifacts were evaluated as a possible method of locating and characterizing kidney stones. Doppler ultrasound scanning was used to evaluate 47 stones of different types and sizes in the range 1.31 –55.76 mm2 in cross-sectional area (average = 9.65 mm2). An isolated stone study was used to understand the behavior of the TAs.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
AbstractExtracorporeal shock wave lithotripsy (SWL) is less invasive compared to the other invasive modalities of stone treatment that are gaining popularity. Hence, methods to improve the efficacy of SWL are desirable. We studied the effectiveness of dual frequency on the efficacy of stone fragmentation, but minimizing treatment time. A phantom 10  mm spherical BegoStone was fragmented in vitro in a kidney model using an electromagnetic lithotripter (Storz MODULITH®SLX-F2). A total of 78 stones were fragmented each with 3000 shocks at 60  Hz or 120 Hz or a dual frequency (DF) of 60–120 Hz. Fo...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
Journal of Endourology, Ahead of Print.
Source: Journal of Endourology - Category: Urology & Nephrology Authors: Source Type: research
AbstractBackgroundAlthough high-density lipoprotein (HDL) modulates many cell types in the cardiovascular system, little is known about HDL in the kidney. We assessed urinary excretion of apolipoprotein AI (apoAI), the main protein in HDL.MethodsWe enrolled 228 children with various kidney disorders and 40 controls. Urinary apoAI, albumin, and other markers of kidney damage were measured using ELISA, apoAI isoforms with Western blot, and renal biopsies stained for apoAI.ResultsPatients followed in nephrology clinic had elevated urinary apoAI vs. controls (median 0.074  μg/mg; interquartile range (IQR) 0.0160–...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
To identify risk factors associated with recurrent kidney stones in a paediatric cohort in a Belgian tertiary centre.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
Few medtech sectors are as hot as surgical robotics is right now, so it comes as no surprise that analysts tried to dig for information about Johnson &Johnson's plans for the market during the company's third-quarter earnings call Tuesday. "I couldn't be more bullish around how J&J is going to create value in this space," Ashley McEvoy, EVP and worldwide chairman of Johnson &Johnson's medical device segment, said during the call in response to an analyst's question about surgical robotics. "The goal that we're trying to achieve is really to make medical interventions smarter, less invasive, more pers...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
This study assesses the feasibility and effectiveness of using a three-dimensional (3D) printing model for preoperative planning in the treatment of full staghorn stones, specifically in the selection of the most optimal calyx for puncture. Twelve patients were enrolled in this trial. A preoperative CT taken in prone position was performed on each of the patients. 3D models were reconstructed using digital imaging and 3D printers. Three identical models were printed for each patient. Three puncture sites from the upper-, middle-, and lower-pole calyces of the kidney models were selected for simulation of percutaneous nephr...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
Authors: PMID: 31613572 [PubMed - in process]
Source: American Family Physician - Category: Primary Care Tags: Am Fam Physician Source Type: research
Crystal Growth&DesignDOI: 10.1021/acs.cgd.9b01077
Source: Crystal Growth and Design - Category: Chemistry Authors: Source Type: research
The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as “0.1 mg/kg/day divided BID-QID for children, 30–60 mg per day divided BID-QID for adults”.
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
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