Human umbilical cord tissue stem cells and neuronal lineages in an injectable caffeic acid –bioconjugated gelatin hydrogel for transplantation

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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Source: Annals of Hematology - Category: Hematology Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractTo investigate the effect of chronic graft-versus-host disease (cGVHD) on the outcomes of acute myeloid leukemia (AML) patients who relapsed after allogenic hematopoietic cell transplantation, we performed a retrospective analysis on 218 patients with a median follow-up of 21.4 (3.4 –179.6) months. A total of 103 patients developed cGVHD, with a 2-year cumulative incidence of 48.9% (95% CI 42.1–55.7%). The estimated 3-year overall survival was 85.7% (95% CI 75.7–95.7%), 48.8% (95% CI 31.7–66.0%), and 54.1% (95% CI 44.3–63.8%) for patients with limited cGVHD, extensiv e cGVHD, and ...
Source: Annals of Hematology - Category: Hematology Source Type: research
Researchers from Daegu Gyeongbuk Institute of Science and Technology (DGIST) in South Korea have developed a new microrobot that can precisely deliver therapeutic cells to very specific parts of the brain. Their work, recently published in Science Ro...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Nanomedicine Neurology Neurosurgery Source Type: blogs
The authors of this open access paper review the aging of the kidney and consider the prospects for using factors from young blood as a means of rejuvenation. This is a fairly narrow view, as there are many other approaches that should produce rejuvenation of the aged kidney, ranging from those close to realization, such as senolytic therapies to clear senescent cells, or various approaches to stem cell therapy, to those yet to be achieved, meaning much of the rest of the SENS agenda of rejuvenation biotechnologies to repair the damage that causes aging. Nonetheless, after so many years of trying to persuade the research c...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
It is well known that the most commonly available forms of stem cell therapy produce benefits via signaling on the part of the transplanted cells, which soon die, rather than via any sort of integration of these cells into tissues. These treatments use varieties of what are called mesenchymal stem cells, which is actually a poorly defined, broad category. One clinic's mesenchymal stem cells are usually meaningfully different from those of the next. Nonetheless, these therapies fairly reliably reduce chronic inflammation. This can allow for improved regeneration in patients, but that outcome is much less reliable in practic...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The speed and quality of immune reconstitution are important factors in clinical outcomes after hematopoietic stem cell transplantation (HSCT). Immune reconstitution in this setting is a stepwise process in which the innate immune system starts to recover before the adaptive system [1]. In particular, the timing of T and B lymphocyte reconstitution has been associated with increased risks of post-transplantation opportunistic infections and transplant-related mortality in various studies [2 –7]. Further, the timing of reconstitution of the various lymphocyte subtypes and their functions are related to clinical outcom...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Objective: The present study aimed to investigate the effects of Mesenchymal stem cells/glial cell line derived neurotrophic factor (MSCs/GDNF) transplantation on nerve reconstruction in rats with intracerebral hemorrhage. Methods: GDNF transduction to MSCs was using adenovirus vector pAdEasy-1-pAdTrack-CMV prepared. Intracerebral hemorrhage (ICH) was induced by injection of collagenase and heparin into the caudate putamen. At the third day after a collagenase-induced ICH, adult male SD rats were randomly divided into saline group, MSCs group and MSCs/GDNF group.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Psychiatric care is an important aspect of Hematopoietic Stem Cell Transplantation (SCT) because of high rates of acute and chronic anxiety, depression, delirium, cognitive impairment [1], decreased quality of life, body image disturbances, and post-traumatic stress [2, 3]. The use of psychosocial rating scales is potentially useful to integrate psychiatric evaluation findings into medical risk stratification models in transplantation, but has not been studied in SCT. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) is a structured assessment tool with demonstrated inter-rater reliability.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Authors: Bewersdorf JP, Stahl M, Zeidan AM Abstract Key paper evaluation: Craddock C, et al. Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia. J Clin Oncol. 2019; 37: 580-8. Allogeneic hematopoietic stem cell transplant (allo-HSCT) is the only potentially curative treatment for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, most patients relapse after allo-HSCT and treatment options are limited. Craddock et al. reported recently in the Journal of Clinical Oncology results from a ...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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