A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry

Epilepsy is the most common chronic disabling condition of the nervous system and it constitutes a major global health problem [1]. The World Health Organization reported that approximately 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally [2]. For all epileptic patients, 70% are expected to enter remission, which is defined as being seizure-free with medication for 5 or more years [3]. In recent years, there has been a growth in reports of antiepileptic drugs (AEDs) being misused on their own or in combination with other drugs of abuse in a variety of toxicological case types, including drug abuse, suicide, overdose and drug-facilitated crime [4].
Source: Legal Medicine - Category: Forensic Medicine Authors: Source Type: research