Chronic otitis media with effusion in chronic sinusitis with polyps.
Chronic otitis media with effusion in chronic sinusitis with polyps. Ear Nose Throat J. 2018 Aug;97(8):E13-E18 Authors: Daval M, Picard H, Bequignon E, Bedbeder P, Coste A, Ayache D, Escabasse V Abstract The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. We conducted a cross-sectional study of 80 consecutively presenting patients-42 males and 38 females, aged 15 to 76 years (median: 48)-who were diagnosed with CRSwNP. Our aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients. The severity of CRSwNP was assessed on the basis of nasal symptoms, endoscopic nasal examinations, and Lund-Mackay staging scores. In addition to demographic data, we obtained information on each patient's history of otitis, otoscopic findings, and the results of pure-tone audiometry and tympanometry. We then compared the data between CRSwNP patients with OME (n = 20) and those without (n = 60). In the OME group, a conductive hearing loss was present in 16 patients (80.0%); all patients in the control group had normal hearing. With regard to symptoms, only rhinorrhea appeared to be more common in patients with OME than in those without, although the difference was not statistically significant. We found no significant difference in nasal polyposis grades between the two groups. Also...
Transcription infidelity (TI) is a mechanism that increases RNA and protein diversity. We found that single-base omissions (i.e., gaps) occurred at significantly higher rates in the RNA of highly allergenic legumes. Transcripts from peanut, soybean, sesame, and mite allergens contained a higher density of gaps than those of nonallergens. Allergen transcripts translate into proteins with a cationic carboxy terminus depleted in hydrophobic residues. In mice, recombinant TI variants of the peanut allergen Ara h 2, but not the canonical allergen itself, induced, without adjuvant, the production of anaphylactogenic specific IgE...
This study has the potential to transform the diagnosis and treatment of allergic disorders.
Conclusion: Findings suggest that DMRT3 could be potentially involved in nasal polyps development in N-ERD patients. Known functions of DMRT3 include nucleic acid binding and highly expressed during embryonic development. Several genes are downregulated, hinting dedifferentiation phenomenon in N-ERD polyps. However, further studies are required to confirm the exact mechanism of polyps formation in N-ERD patients.
Older adults who take daily low-dose aspirin may be more likely than those who don't to be diagnosed with advanced cancers and to die from them, a randomized trial suggests.Reuters Health Information
We read with interest the article by Turse et al.1 The authors report, in a retrospective study, that deep sedation (DS) had no benefit compared with moderate sedation (MS) for adenoma detection rate (ADR) and polyp detection rate (PDR) in average-risk patients undergoing screening colonoscopy for colorectal cancer. The study populations were similar for both groups, including relatively healthy patients. A highlighted strength of the study was that the focus on average-risk patients examined at the same center minimized possible confounding factors of prior investigations.
Colonoscopy screening comes with a significant cost. If you sum up the costs due to health care personnel, endoscopy technology, facilities, and histopathology, colonoscopy is among the most expensive diagnostic procedures, with estimates comparable with whole-body CT or magnetic resonance imaging. When these costs are projected at population level, the absolute magnitude is exceptional, inasmuch as it is estimated to correspond to an annual gross expenditure of more than U.S. $775 million.1
A new study found that serious allergic reactions (anaphylaxis) triggered by peanuts jumped 85% when kids were trick or treating.
Publication date: Available online 21 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): George Makedonas, Satish K. Mehta, Richard A. Scheuring, Robert Haddon, Brian E. Crucian
Publication date: Available online 20 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Chandra Vethody, Roger Yu, Jacob M. Keck, Michelle K. Onasch, Cosby A. Stone, Elizabeth J. Phillips
A new study has suggested that some patients who make this switch may experience"double immunosuppression" – very low levels of both T and B cells, and therefore be at increased risk for infection.Medscape Medical News