A Pilot, Exploratory, Randomized, Phase 2 Safety Study Evaluating Tumor Cell Mobilization and Apheresis Product Contamination in Patients Treated With Granulocyte Colony Stimulating Factor Alone or Plus Plerixafor

Autologous transplantation of hematopoietic stem cells (HSCs) is a widely used strategy for hematologic and immunologic recovery following high-dose chemotherapy for hematologic malignancies, such as multiple myeloma (MM), non-Hodgkin lymphoma, Hodgkin's disease, and other cancers, including germ-cell tumor and neuroblastoma [1]. After the induction of patients ’ chemotherapy, regardless of whether or not the chemotherapy has been accompanied by cytokine (usually granulocyte colony stimulating factor [G-CSF]) treatment, or after the patient has received treatment with a cytokine alone (such as G-CSF) without associated chemotherapy, hematopoietic stem ce lls for transplantation are usually obtained from the peripheral blood.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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