A Pilot, Exploratory, Randomized, Phase 2 Safety Study Evaluating Tumor Cell Mobilization and Apheresis Product Contamination in Patients Treated With Granulocyte Colony Stimulating Factor Alone or Plus Plerixafor
Autologous transplantation of hematopoietic stem cells (HSCs) is a widely used strategy for hematologic and immunologic recovery following high-dose chemotherapy for hematologic malignancies, such as multiple myeloma (MM), non-Hodgkin lymphoma, Hodgkin's disease, and other cancers, including germ-cell tumor and neuroblastoma . After the induction of patients ’ chemotherapy, regardless of whether or not the chemotherapy has been accompanied by cytokine (usually granulocyte colony stimulating factor [G-CSF]) treatment, or after the patient has received treatment with a cytokine alone (such as G-CSF) without associated chemotherapy, hematopoietic stem ce lls for transplantation are usually obtained from the peripheral blood.
What impact do antibiotic-related changes of the gut microbiome have on efficacy of immune-checkpoint inhibitors?Annals of Oncology
Could this novel intervention help improve immunosuppressive medication adherence among adult kidney transplant recipients?American Journal of Transplantation
For patients with life-altering illnesses or anyone just getting older, it helps to roll with the punches and make the best of the here and now.
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
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Publication date: Available online 19 January 2020Source: Food Research InternationalAuthor(s): Caiyu Lei, Xiangyi Tang, He Li, Hualei Chen, Shujuan YuAbstractThe grape seed extract (GSE) hybridized with medium-chain saturated fatty acids (decanoic acid) exhibited higher lipophilicity, antioxidant activity, and anti-proliferative activity than its parents. The chemical structures of individual hybridized GSE derivatives were identified as 3'-O-decanoyl catechin, 3′-O-decanoyl epicatechin, 3', 5'-2-O-decanoyl epigallocatechin, and 3', 4', 3'', 5''-4-O-decanoyl epicatechin gallate by HPLC-MS2 and 1H and 13C NMR. For gr...
Women whose periods stop before the age of 40 are at greater risk of diabetes, heart disease, strokes, asthma and breast cancer, the study found. The UK menopause average is 51.