Risk Factors for Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation

Parainfluenza virus (PIV) is a respiratory virus commonly detected after hematopoietic cell transplantation (HCT) [1-3]. Human PIV has four subtypes, numbered 1 through 4 [4, 5]. PIV type 3 (PIV-3) is the most common subtype and a frequent cause of outbreaks among HCT recipients [6-8]. PIV can progress from upper respiratory tract infection (URTI) to lower respiratory tract disease (LRTD), resulting in mortality as high as 40-50% [3, 9-11]. Identification of risk factors for progression to LRTD and their relative importance is critical in clinical practice and designing clinical trials of novel drugs and immunotherapies.

Source: Biology of Blood and Marrow Transplantation - August 24, 2018 Category: Hematology Authors: Sachiko Seo, Hu Xie, Wendy M Leisenring, Jane M Kuypers, Farah T Sahoo, Sonia Goyal, Louise E Kimball, Angela P Campbell, Keith R Jerome, Janet A Englund, Michael Boeckh Source Type: research