Risk Factors for Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation
Parainfluenza virus (PIV) is a respiratory virus commonly detected after hematopoietic cell transplantation (HCT) [1-3]. Human PIV has four subtypes, numbered 1 through 4 [4, 5]. PIV type 3 (PIV-3) is the most common subtype and a frequent cause of outbreaks among HCT recipients [6-8]. PIV can progress from upper respiratory tract infection (URTI) to lower respiratory tract disease (LRTD), resulting in mortality as high as 40-50% [3, 9-11]. Identification of risk factors for progression to LRTD and their relative importance is critical in clinical practice and designing clinical trials of novel drugs and immunotherapies.
The coronavirus outbreak started in central China and has left 41 people dead.
In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong province, China, after a visit to Wuhan, and an additional family member who did not travel to Wuhan. Phylogenetic analysis of genetic sequences from these patients were done.FindingsFrom Jan 10, 2020, we enrolled a family of six patients who travelled to Wuhan from Shenzhen between Dec 29, 2019 and Jan 4, 2020. Of six family members who travelled to Wuhan, five were identified as infected with the ...
Publication date: Available online 24 January 2020Source: The LancetAuthor(s): David L Heymann
Publication date: Available online 24 January 2020Source: The LancetAuthor(s): Chen Wang, Peter W Horby, Frederick G Hayden, George F Gao
President Xi Jinping said China was facing a "grave situation" as the death toll from the coronavirus outbreak jumped to 42, overshadowing celebrations of the Lunar New Year that began on Saturday.
Chinese communities around the world greeted the Year of the Rat on Saturday with dances and parades, although celebrations were marred by worries about the coronavirus outbreak that has upended Lunar New Year festivities in China.
China says it has a total of 1,372 cases of the coronavirus nationally with 41 people having died, as of 6 p.m. local time (1000 GMT) on Saturday, according to state-owned CCTV.
An outbreak of a new coronavirus that began in the central Chinese city of Wuhan has killed 41 people and infected more than 1,300 globally.
Chinese President Xi Jinping, saying the country is facing a grave situation, held a politburo meeting on measures to fight a coronavirus outbreak concentrated in the central city of Wuhan, state television reported on Saturday.
This study compared 367 worldwide equine strains using multilocus sequence typing according to the geographical origin, isolation year and equine breed. The strains were divided into 49 sequence types (STs), including 10 described for the first time. Three major and three minor clonal complexes (CCs), and 11 singletons, were identified. The genetic heterogeneity was low (0.13 STs/strain) despite the wide diversity of geographical origins (n = 16), isolation years (1977 to 2018) and equine breeds (n = 18). It was highest outside Europe and in the 1977-1997 period; current major STs and CCs alread...