KIR Donor Selection: Feasibility in Identifying Better Donors

The preferred unrelated donor is HLA allele-matched [1, 2], young, not previously alloimmunized (through pregnancy or transfusion) [3] and in some, but not all reports, for certain recipients, CMV seronegative [4]. However, other factors have been proposed to identify better donors yielding prompt graft recovery and improved post-transplant outcomes. We previously reported on KIR B haplotype donors and their association with reduced relapse risks and improved disease free-survival (DFS) after unrelated donor (URD) transplants for AML [5,6,7].

Source: Biology of Blood and Marrow Transplantation - August 24, 2018 Category: Hematology Authors: Daniel Weisdorf, Sarah Cooley, Tao Wang, Elizabeth Trachtenberg, Michael D. Haagenson, Cynthia Vierra-Green, Stephen Spellman, Ashley Spahn, Jenny Vogel, Hati Kobusingye, Todd Fehninger, Ann Woolfrey, Steven Devine, Maureen Ross, Edmund K. Waller, Ronald Source Type: research