The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair

Cantharidin is an inhibitor of protein phosphatase 2  A (PP2A), and has been frequently used in clinical practice. In our previous study, we proved that cantharidin could arrest cell cycle in G2/M phase. Since cells at G2/M phase are sensitive to radiotherapy, in the present study, we investigated the radiotherapy-sesitization effect of cantharidin and the potential mechanisms involved.

Source: Pancreatology - August 24, 2018 Category: Gastroenterology Authors: Meng-Dan Xu, Shu-Ling Liu, Bei-Bei Zheng, Jing Wu, Meng-Yao Wu, Yan Zhang, Fei-Ran Gong, Min Tao, Junning Zhang, Wei Li Source Type: research