Low-carb fairy tales
Conclusion: Premarin INCREASED breast cancer, INCREASED endometrial cancer, INCREASED cardiovascular death, even accelerated dementia. And this has been the story over and over again: Conclusions drawn in observational studies have proven to be flat wrong about 4 times out of 5. This hasn’t stopped people like Frank Sacks and Walter Willett, through the observational Physicians’ Health Study and Nurses’ Health Study to, time and again, declare observational findings as fact. Unfortunately, even the USDA buys this observational fiction, incorporating the findings of observational studies in their dietary guidelines. So the observational data reported in this study cannot be used to draw conclusions. It would be nice if we could refute the claims being made with randomized, prospective data, but there are none. However, there are abundant data that look at various biomarkers that demonstrate the metabolic advantages of low-carb eating. Among improved biomarkers are: Reduced HbA1c, fasting glucose, insulin, reduced insulin resistance Reduced triglycerides (due to lack of carbs/sugars to fuel liver de novo lipogenesis, i.e., conversion of sugars to triglycerides ) Reduction or elimination of small LDL particles Reduced severity of postprandial (after-meal) lipoproteins (especially VLDL) Reduced blood pressure Weight loss including from visceral fat Reduced inflammatory markers such as c-reactive protein, IL-2, TNF-alpha Reversal of fatty liver Low-fa...
Athletic performance and physique have been closely associated with diet and nutrition for ages. One such diet is the ketogenic diet, increasingly favored by many athletes.ACC.org
Publication date: Available online 30 March 2020Source: Food HydrocolloidsAuthor(s): Farhad Alavi, Zhigang Tian, Lingyun Chen, Zahra Emam-Djomeh
Contributors : David Ulmert ; Robert J KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted alpha therapy.
Contributors : Lewis Liu ; Sonya A MacParland ; Jeff C Liu ; Gary D Bader ; Ian D McGilvraySeries Type : Expression profiling by high throughput sequencingOrganism : Marmota monaxWe characterized the identity of hepatic macrophages from the uninvolved liver of a WHV-positive (area with no visible tumor) tumor bearing woodchuck that take up NPs using RNA-sequencing (RNA-seq). Data from WHV-infected animal from experiment 3.
In this study, we identified reliable miRNA clusters that can be used to subclassify HNSCC tumors as well as other squamous tumors of other anatomic locations. An institutional discovery cohort was generated using miRNA expression data from microarrays, and this was validated using publicly available next-generation microRNA sequencing data from TCGA. Further analysis of these subtypes revealed distinct biological and clinical features of HNSCC tumors based on the miRNA expression profiles, which provides new insights into the pathogenesis and treatment of HNSCC.
Contributors : Samir Devalaraja ; Tsun K To ; Ian W Folkert ; Ramakrishnan Natesan ; Zahidul Alam ; Minghong Li ; Yuma Tada ; Konstantin Budagyan ; Mai Dang ; Li Zhai ; Graham P Lobel ; Gabrielle E Ciotti ; T K Eisinger-Mathason ; Irfan A Asangani ; Kristy Weber ; M C Simon ; Malay HaldarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (...
Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
CONCLUSION: network analyses confirm GDF15 as upregulated with calorie restriction-induced weight loss, concomitantly to macrophages markers.
Contributors : Heloisa H Milioli ; Neil PortmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we characterise the response of models of ER-positive breast cancer to treatment with the small molecule MDM2 inhibitor NVP-CGM097, a dihydroisoquinolinone derivative currently evaluated in a phase I clinical trial. We show that NVP-CGM097 reduces tumour cell viability of in vitro and in vivo models of endocrine sensitive, endocrine resistant and palbociclib (CDK4/6 inhibitor) resistant p53 wildtype (p53wt) ER-positive breast cancer. NVP-CGM097 synergises with both fulvestrant and palbo...
Contributors : Hiromu Suzuki ; Akira YorozuSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe identified adipocyte enhancer binding protein 1 (AEBP1) as a novel tumor endothelial marker in colorectal cancer (CRC). To identify target genes of AEBP1 in endothelial cells, we knocked down AEBP1 in human umbilical vein endothelial cells (HUVECs). We found that genes associated with angiogenesis including aquaporin 1 (AQP1) and periostin (POSTN) are downregulated by AEBP1 knockdown in HUVECs, suggesting that AEBP1 may promote tumor angiogenesis through regulating these genes.
More News: Blogging | Breast Cancer | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Children | Coconut Oil | Coconuts | Colon Cancer | Colorectal Cancer | Constipation | Dementia | Diets | Diverticular Disease | Endometrial Cancer | Fatty Liver Disease (FLD) | Heart | Heart Attack | Heart Disease | Insulin | Kidney Stones | Liver | Meat | Nursing | Nutrition | Poisoning | Premarin | Saturated Fat | Study | Sugar | Urology & Nephrology | Vegetarian | Weight Loss | Wheat | Women