Design, synthesis and identification of novel substituted isothiochromene analogs as potential antiviral and cytotoxic agents

In this study, we present the synthesis of novel isothiochromenes, thiazolidonone, thiazinone, arylidines, triazoles, and pyrimidinone compounds based on the starting material 3-amino- isothiochromene-4-carbonitrile3. The chemical structures were confirmed using spectroscopic methods and elemental analyses. These compounds were screened for their in vitro antiviral and antitumor activities. Compounds10a-c and22a-b showed activity against herpes simplex virus-1 (HSV-1) and human immunodeficiency virus-1 (HIV-1). Compounds15 and21a-b exhibited activity against various types of cancer cell lines.Compounds22a-b and10a-c showed to be active against herpes simplex virus-1 (HSV-1) and virus-1 (HIV-1). Also, the products21a-b and15 proved to a wide extent antitumor activity
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research