PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essentia...

Source: Stem Cell Research and Therapy - August 23, 2018 Category: Stem Cells Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu Tags: Research Source Type: research