Low on Energy? An energy supply-demand perspective on stress and depression
Publication date: Available online 23 August 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Leif Østergaard, Martin Balslev Jørgensen, Gitte Moos KnudsenAbstractAre energy demands too high, or our energy resources either too low or inappropriately prioritized, as we develop stress and/or depression? We review evidence of dysregulated cellular energy homeostasis and energy depletion in stress and depression, identifying factors that might limit energy substrate availability. Resetting of cellular energy-sensors, splanchnic hypoxia, and catecholamine effects on blood viscosity emerge as mechanisms that might disrupt normal energy homeostasis, accelerate cell injury, and cause depression-like symptoms in severe or prolonged stress. In particular, a vicious cycle of capillary dysfunction, cellular hypoxia, and inflammation emerges as a mechanism, by which prolonged stress might accelerate the development of diseases, including depression, in later life. Oxygen is a substrate for both serotonin- and ATP-synthesis, and the review therefore analyzes evidence of reduced oxygen availability in neurological diseases with high incidence of depression.Blood supply and oxygen availability are also keys to the inference of neuronal activity by functional neuroimaging. We review how neurotransmitters interfere with blood flow regulation, affecting interpretations of neuroimaging studies in stress and depression.Graphical abstract
Publication date: Available online 2 June 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Sabine Moehner, Kerstin Becker, Jens A. Lange, Sophia von Stockum, Klaas Heinemann
Publication date: Available online 2 June 2020Source: Journal of ColoproctologyAuthor(s): Nasrin Sarabi
Authors: Yang T, Wang X, Liu L, Chen H, Wang N Abstract BACKGROUND Depression is the 5th most prevalent disorder adversely affecting the health of humans worldwide. The present study evaluated the antidepressant effect of ginkgolide-platinum(II) complex in vivo in a mice model of CMS-induced depression. MATERIAL AND METHODS Depression was induced in mice by social isolation followed by chronic mild stress. After stress, the mice were assigned randomly to a model group, a 3 mg/kg group, a 6 mg/kg group, and a 12 mg/kg group. The mice in the 3 treatment groups were intraperitoneally injected with a single dose of 3.0...
Publication date: Available online 2 June 2020Source: Journal of Psychiatric ResearchAuthor(s): Michael Frey, Viola Obermeier, Rüdiger von Kries, Gerd Schulte-Körne
Publication date: Available online 2 June 2020Source: Journal of Psychiatric ResearchAuthor(s): Felipe Bauer P. Costa, Eduardo Trachtenberg, Aline Boni, Lucas Primo de Carvalho Alves, Pedro Vieira da Silva Magalhães, Neusa Sica Rocha
Publication date: Available online 2 June 2020Source: Neuroscience LettersAuthor(s): Ke-Wei Chang, Hang-Fan Zong, Meng Wang, Mohammad Yasir Rizvi, Saema Iffat Neha, Wei-Na Yang, Sheng-Feng Ji, Yan-Bing Ma, Yi-Hua Qian
Publication date: Available online 2 June 2020Source: NeuroscienceAuthor(s): Takuma Inoshita, Tomoo Hirano
The hidden links between mental disorders (Nature): In 2018, psychiatrist Oleguer Plana-Ripoll was wrestling with a puzzling fact about mental disorders. He knew that many individuals have multiple conditions — anxiety and depression, say, or schizophrenia and bipolar disorder. He wanted to know how common it was to have more than one diagnosis, so he got his hands on a database containing the medical details of around 5.9 million Danish citizens. He was taken aback by what he found. Every single mental disorder predisposed the patient to every other mental disorder — no matter how distinct the symptoms. &ldquo...
Many physicians say the traumatic experiences of being on the front line leave them mentally exhausted, guilt-ridden, and depressed. Here's where to find resources to help your mental health at this time.Medscape Medical News
For most Americans, 2020 has already been a rough year — and it’s not even half over. A pandemic, natural disasters, economic decline, and, for many, the loss of a job have taken a toll on their mental health. “Stress is particularly acute when you’re experiencing a situation that is outside of your control,” says Dr. Kerry Ressler, professor of psychiatry at Harvard Medical School. “You may feel stuck, frozen, or helpless.” After a traumatic period, even when things settle down, it can be difficult to move on and regain a sense of normalcy. Reducing stress and regaining your footi...