DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathway.

CONCLUSIONS: The protection of rBMVECs from hypoxia/high-glucose induced impairment by DPP-4 inhibitors may be mediated by the SIRT1/HIF-1α/VEGF pathway. PMID: 30136405 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30136405?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - August 23, 2018 Category: Neuroscience Authors: Mi DH, Fang HJ, Zheng GH, Liang XH, Ding YR, Liu X, Liu LP Tags: CNS Neurosci Ther Source Type: research