STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription.

CONCLUSION: In summary, STAT3 gene was a transcriptional regulator of FOXP1. Depleted STAT3 restrained cell proliferation and invasion, promoted cell apoptosis in glioma cells. This molecular mechanism between STAT3 and FOXP1 can serve as a therapeutic target for glioma treatment.
PMID: 30134017 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - August 22, 2018 Category: Molecular Biology Authors: Sun X, Wang J, Huang M, Chen T, Chen J, Zhang F, Zeng H, Xu Z, Ke Y Tags: J Cell Mol Med Source Type: research