Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model.

Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model. Drug Dev Ind Pharm. 2018 Aug 22;:1-49 Authors: Al-Okbi SY, Mohamed DA, Hamed TE, Abd El-Alim SH, Kassem AA, Mostafa DM Abstract Chronic renal failure (CRF) is among the major health problems that could lead to increased morbidity and mortality among population. "Nutraceuticals" is an emerging field for natural agents from plant foods that could reduce the progression of such disease. Many newly developed drugs are having bioavailability problems owing to their water insolubility. Liquisolid technique is one of the promising technological approaches to increase solubility and hence, drug absorption. The aim of the present research was to prepare and evaluate the renoprotective effect of walnut extracts liquisolid formulations in CRF rat model. Saturation solubility study claimed PEG 400 and Tween 20 as good solubilizers for walnut extracts, thus chosen for preparation. The angle of slide was determined for the carrier; microcrystalline cellulose and coating material; silicon dioxide and liquid load factor was evaluated. Eight liquisolid systems were prepared employing 25% and 50% of liquid medication. Their flow and compressibility parameters showed good properties. Dissolution study was more in favor with formulations prepared using PEG 400. Of these, formulation F8 comprising carrier/coat ratio (10:1)...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research