Clinical characteristics of patients with bacteraemia due to the emergence of mcr-1-harboring Enterobacteriaceae in humans and pigs in Taiwan

In the era of widespread antibiotic-resistant bacteria, the number of multidrug-resistant (MDR) gram-negative bacteria has been continuously increasing [1-4]. Drug resistance in species belonging to Enterobacteriaceae is no exception, and the emergence of carbapenem resistance has been found among Enterobacteriaceae, and it is recognized as a global public health issue [5-7]. The therapeutic option for MDR organism is limited, and colistin is considered as the last drug of choice [11-14]. However, since the first identified mcr-1-encoding plasmid-mediated colistin-resistant Enterobacteriaceae in China [11], many regions, including Europe [12, 13] and Taiwan [14, 15], have reported mcr-1-positive Enterobacteriaceae isolates in both animals and humans.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research