HCV Treatment Initiation in Persons With CKD in the DAAs Era HCV Treatment Initiation in Persons With CKD in the DAAs Era

New DAA regimens have now been approved for treatment of HCV infected persons with advanced chronic kidney disease. Are treatment rates improving in this population?Liver International
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Authors: Park S, Jeong TD Abstract The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation can be calculated according to race, sex, and creatinine concentration (subgroup equation) or in the form expressed by one equation (single equation). Minor differences in the constants used in the CKD-EPI equations (subgroup vs single equations) could result in a significant difference in the estimated glomerular filtration rate (eGFR). We evaluated the impact of this difference in 79,709 Korean patients. The eGFR was calculated as an integer using the single and subgroup CKD-EPI equations. ...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Publication date: Available online 15 November 2018Source: Veterinary MicrobiologyAuthor(s): Kripitch Sutummaporn, Kazuhiko Suzuki, Noboru Machida, Tetsuya Mizutani, Eun-sil Park, Morikawa Shigeru, Tetsuya FuruyaAbstractFeline morbillivirus (FeMV) is an emerging member of morbillivirus discovered in 2012. Although association of FeMV infection with kidney diseases in cats has been suggested, the pathogenicity of the virus has not been clear to date. To study the association between FeMV infection and pathological changes in kidney tissues of infected cats, we performed immunohistochemistry and immunofluorescent assays to d...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 8 November 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Siyun Xiang, Qiman Jin, Fangyi Xu, Ying Yao, Wangqun Liang, Xuezhi Zuo, Ting Ye, Chenjiang YingAbstractThe present study aims to assess arsenic accumulation and explore its association with renal function and biomarkers of CVD risk in chronic kidney disease patients receiving continuous ambulatory peritoneal dialysis (CAPD). The serum was collected from 87 CAPD patients and 26 healthy subjects between 2015 and 2016. The arsenic concentration was measured by inductively coupled plasma mass spectrometer. Clin...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Conclusion: MAGI2 identified by WGCNA regulates cytoskeletal rearrangement in podocytes, with its loss predisposing to proteinuria and CKD.Cell Physiol Biochem 2018;51:244 –261
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
[This is Africa] Dr. Nolubabalo Nqebelele has attained a PhD in Nephrology, making her a specialist in Chronic Kidney Disease (CKD). Her achievement makes her the first Black woman to earn a PhD in Internal Medicine at the University of the Witwatersrand, a top South African college.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
For the past 40 years, certain laboratory mice in Australia and the US have been unexpectedly dying in middle age, but the cause has remained elusive. A novel member of the parvovirus family appears to be the culprit. These unexpected deaths of laboratory mice are caused by kidney disease, as these organs appear shrunken and […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information chronic kidney disease inclusion body nephropathy interstitial fibrosis intranuclear inclusion bodies koch's postulates parvovirus tubular necrosis viral viruses Source Type: blogs
Abstract Background: The cardio-ankle vascular index (CAVI) is a physiologic marker reflecting arterial function. There have been no prospective studies investigating the relationship between CAVI and cardiovascular events in patients with chronic kidney disease (CKD). The aim of this prospective study was to assess the clinical usefulness of CAVI as a predictor of primary cardiovascular events in patients with CKD. Methods: The study enrolled 460 outpatients with CKD but no history of cardiovascular disease (152 men and 308 women; mean ± standard deviation age, 74 ± 12 years). Patients were ass...
Source: Clin Med Res - Category: Research Authors: Tags: J Clin Med Res Source Type: research
The kidneys consume a large amount of energy to regulate volume status and blood pressure and to excrete uremic toxins. The identification of factors that cause energy mismatch in the setting of chronic kidney disease (CKD) and the development of interventions aimed at improving this mismatch are key research imperatives. Although the critical cellular energy sensor 5 ′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is known to be inactivated in CKD, the mechanism of AMPK dysregulation is unknown.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research
ConclusionsThe presence of CKD predicts a significantly lower probability of PREM improvement among fracture patients. An early emphasis on renal function during fracture care should be considered.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
AbstractBackgroundFructose intake may lead to hyperuricaemia, which is associated with increased risk and progression of kidney disease. We aimed to explore the acute effects of fructose loading from different sources, with and without a pizza, on levels of serum uric acid in patients with chronic kidney disease (CKD), type 2 diabetes (T2D) without CKD, and in healthy subjects (HS).MethodsThe study included six HS, and three CKD stage 4 ‐5 and seven T2D patients. Drinks consumed were blueberry drink (17.5 g fructose), Coca‐Cola (18 g fructose) and fructose drink (35 g fructose). The drinks were also comb...
Source: European Journal of Clinical Investigation - Category: General Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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