Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety

Chronic postsurgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP. The authors conducted a systematic literature search of the major medical databases from inception until October 2017. Trials that randomized adults without baseline pain to perioperative lidocaine infusion or placebo were included if they reported on CPSP. The primary outcome was the presence of procedure-related pain at 3 months or longer after surgery. The secondary outcomes of pain intensity, adverse safety events, and local anesthetic toxicity were also assessed. Six trials from 4 countries (n = 420) were identified. Chronic postsurgical pain incidence was consistent with existing epidemiological data. Perioperative lidocaine infusions significantly reduced the primary outcome (odds ratio, 0.29; 95% confidence interval, 0.18-0.48), although the difference in intensity of CPSP assessed by the short-form McGill Pain Questionnaire (4 trials) was not statistically significant (weighted mean difference, −1.55; 95% confidence interval, −3.16 to 0.06). Publication and other bias were highly apparent, as were limitations in trial design. Each study included a statement reporting no adverse events attributable to lidocaine, but systematic safety surveill...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

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AbstractPurposeBreast surgery is an exceedingly common procedure and associated with an increased incidence of acute and chronic pain. Preemptive regional anesthesia techniques may improve postoperative analgesia for patients undergoing breast surgery. The aim of this study was to evaluate the effect of preoperative bilateral serratus plane block on postoperative opioid consumption in patients undergoing breast reduction surgery.MethodsAfter ethical board approval, 40 patients undergoing breast reduction surgery were randomized into 2 groups: control group (Group C,n = 20) and serratus plane block group (Grou...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin.In this experimental study, seventy male Wistar rats with an average weight of 270-320 g were randomly divided into 5 groups: control; sham, that received 25 μl of saline through the spinal catheter; and three experimental groups, that received 5, 10 or 20 mg/kg Melissa officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of Melissa officinalis on ...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
In this study we investigated the actions of endogenous opioids in the mechanism of peripheral analgesia induced by ketamine. The nociceptive threshold for mechanical stimuli was measured in Swiss mice using the Randall and Selitto test. The drugs used in this study were administered via intraplantar injection. Our results demonstrated that non selective opioid receptor antagonism (naloxone), selective μ- and δ-opioid receptors antagonism (clocinamox and naltrindole, respectively) but not κ-opioid receptor antagonism (nor-binaltorphimine NORBNI) antagonized ketamine-induced peripheral antinociception in a do...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Publication date: Available online 11 November 2019Source: Fuß &SprunggelenkAuthor(s): N. Maffulli, R. AicaleAbstractIn the past three decades, the incidence of overuse tendinopathy has risen. Tendinopathy affects also middle-aged overweight patients with no history of increased physical activity. Tendinopathy is the result of a chronic failure of healing response. Several conservative therapeutic options have been proposed.The management of tendinopathy is primarily conservative, and many patients respond to such measures. Eccentric exercises and shock wave therapy provide promising excellent clinical results. H...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
Abstract Despite advances in medicine and numerous agents that counteract pain, millions of patients continue to suffer. Attention has been given to identify novel botanical interventions that produce analgesia by interacting with nociceptive-transducing channels. The aim of this review is to provide an overview of the actual knowledge of Acmella oleracea (L.) and its activities, particularly those that are anti-inflammatory, anti-oxidant, and painkiller. These activities are attributed to numerous bioactive compounds, such as phytosterols, phenolic compounds and N-alkylamides (spilanthol, responsible for many act...
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research
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Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: AMBULATORY ANESTHESIA: Edited by Claude Meistelman Source Type: research
A new study establishes a link between humid, windy days and increased pain in people with arthritis and other conditions that cause chronic pain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news
Subcostal transversus abdominis plane (TAP) block with depot steroids provides durable pain relief in many patients with abdominal pain secondary to chronic pancreatitis, according to an observational study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Anesthesiology News Source Type: news
Publication date: November 2019Source: The Journal of Foot and Ankle Surgery, Volume 58, Issue 6Author(s): James Stimpson, Damien F. Gill, Arman Memarzadeh, Mike Dunne, Laura Perry, Ahmed Magan, Adam Devany, Chandra PasapulaAbstractWe evaluated whether moving the “line of crush” from thigh to the calf before onset of tourniquet-mediated hypertension would prevent or diminish it. We also evaluated any change in pain or functional outcome. Twenty adult patients were recruited and randomly assigned to either control or intervention groups. Inclusion criteria: any willing participant>18 years old with foot and/o...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
e F PMID: 31673752 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
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