Inactivation of Caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis

Cholestasis refers to a decrease in bile flow due to impaired secretion by hepatocytes or obstruction of the intra- or extrahepatic bile ducts. In humans, the most prominent disease is biliary obstruction of the common bile duct by gallstones. Other diseases include primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or biliary atresia (BA). Experimental surgical ligation of the common bile duct (BDL) is the standard experimental model of obstructive cholestatic injury [1]. BDL causes complete biliary obstruction and accumulation of toxic bile acids in liver and serum as observed in patients.

Source: Journal of Hepatology - August 22, 2018 Category: Gastroenterology Authors: Francisco Javier Cubero, Jin Peng, Lijun Liao, Huan Su, Gang Zhao, Miguel Eugenio Zoubek, Ricardo Macias-Rodriguez, Astrid Ruiz-Margain, Johanna Rei ßing, Henning W. Zimmermann, Nikolaus Gassler, Tom Luedde, Christian Liedtke, Maximilian Hatting, Christi Source Type: research