Genomic path to panresistance in a clinical isolate of Klebsiella pneumoniae

Carbapenem-resistant Klebsiella pneumoniae (CRKP) have spread through tertiary hospitals worldwide during the last decades [1]. Some sequence types have been particularly successful producing outbreaks in clinical settings and leading to endemic situations, with hundreds of affected patients [2]. Over the years, antibiotic pressure has led to the rise and dissemination of strains with increased resistance spectra. These strains have been called multidrug resistant (MDR) when more than three antimicrobial families were affected or extensively drug resistant (XDR) when only one or two antimicrobial families remain active.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research