Chronic in  vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes

In the heart, slow delayed rectifier channels provide outward currents (IKs) for action potential (AP) repolarization in a region- and context-dependent manner. In diseased hearts, chronic elevation of angiotensin II (Ang II) may remodel IKs in a region-dependent manner, contributing to atrial and ventricular arrhythmias of different mechanisms.

Source: Heart Rhythm - August 1, 2018 Category: Cardiology Authors: Dimitar P. Zankov, Fadi N. Salloum, Min Jiang, Gea-Ny Tseng Source Type: research