Tailoring a Plasmodium vivax Vaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors [Microbial Immunity and Vaccines]

We examined immunity elicited by these vaccines in the context of two adjuvants approved for human use (AddaVax and Matrix-M). Matrix-M supported the highest anti-PvCSP antibody titers when combined with Rv21, and, interestingly, mixing PvCSP Rv21 and PvTRAP viral vectors enhanced immunity to malaria over levels provided by single vaccines.

Source: Infection and Immunity - August 22, 2018 Category: Infectious Diseases Authors: Atcheson, E., Bauza, K., Salman, A. M., Alves, E., Blight, J., Viveros-Sandoval, M. E., Janse, C. J., Khan, S. M., Hill, A. V. S., Reyes-Sandoval, A. Tags: Microbial Immunity and Vaccines Source Type: research