A Bystander Effect of Irradiated Recipients on Transplanted Human Hematopoietic Stem Cells

Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for various hematological disorders. As the main component in various host conditioning regimens for HSCT, total body irradiation (TBI) is still commonly used in the treatment for multiple myeloma, lymphoma and acute lymphoblastic leukemia. But it can also cause negative effects on the transplanted HSCs. We have previously demonstrated an acute negative bystander effect of irradiated recipients on transplanted mouse HSCs (Shen H et  al, Blood 2012).
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research