Alternative splicing in prostate cancer

Alternative splicing in prostate cancerAlternative splicing in prostate cancer, Published online: 22 August 2018; doi:10.1038/s41571-018-0085-0Androgen receptor (AR) splice variants (AR-Vs) are truncated isoforms of the AR, of which a subset remain constitutively active in the absence of circulating androgens. AR-Vs have been proposed to contribute to therapeutic resistance. The authors of this Review outline the current understanding of the role of the spliceosome in prostate cancer progression and explore the therapeutic utility of manipulating alternative splicing.

Source: Nature Clinical Practice Oncology - August 22, 2018 Category: Cancer & Oncology Authors: Alec Paschalis Adam Sharp Jonathan C. Welti Antje Neeb Ganesh V. Raj Jun Luo Stephen R. Plymate Johann. S. de Bono Source Type: research