Invited commentary

Autophagy is a tightly regulated, multistep intracellular process by which cytoplasmic components are packed in double-membrane vesicles, delivered to the lysosome, and ultimately degraded for energy production and nutrient recycling to maintain cell survival in unfavorable emergent conditions. Whereas autophagy is critically important for cardiovascular homeostasis, dysregulated autophagy is involved in cardiovascular pathologic processes such as atherosclerosis. Although increased autophagy has been reported in experimental and clinical abdominal aortic aneurysms (AAAs),1,2 the role that autophagy plays in AAAs remains unknown.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: From bench to bedside Source Type: research