GSE118646 IL-1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer

Contributors : Jacob Turner ; Xuan Wang ; Derek Blankenship ; Joyce O ’ShaughnessySeries Type : Expression profiling by arrayOrganism : Homo sapiensInflammation affects tumor immune surveillance and resistance to therapy.  Here we show that production of interleukin (IL)-1b in primary breast cancer (BC) tumors is linked with advanced disease. Patients with metastatic HER2-negative BC display a transcriptional signature of inflammation in the blood, which is attenuated after IL1 blockade.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research