Use of thermal and non thermal techniques for assessing compatibility between mirtazapine and solid lipids

Publication date: Available online 20 August 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Randeep Kaur, V.R. SinhaAbstractThe present investigation was aimed at the evaluation of possible interactions between mirtazapine and selected solid lipids that are commonly used to develop solid lipid nanoparticles (SLNs) and nanostructured lipidic carriers (NLCs). The solids lipids explored were palmitic acid, stearic acid, glycerylmonostearate, cutina CPPH, sterotex NF, gelucire 50/13, hydrogenated castor oil and compritol 888 ATO. The techniques used were Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Hot Stage Microscopy (HSM) and Isothermal Stress Testing (IST) studies. In some cases, the DSC results indicated the possibility of drug-solid lipid interactions which was further ruled out by performing HSM studies. Moreover, IST studies were also used to further confirm the compatibility between the drug and selected solid lipids. And the findings from these studies indicated compatibility between mirtazapine and solid lipids that can further be used to develop SLNs or NLCs.Graphical abstract
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research
In conclusion, participants suggest that tailored secondary prevention programming that acknowledges and targets the unique exercise, psychological, and peer support needs of patients with SCAD, as well as increased education for healthcare providers, may be integral to promote patients in their recovery.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study presents an exploratory characterization on the effect of build orientation on deformation behavior of Ti–6Al–4V rods produced through electron beam melting (EBM). Microstructural differences in horizontally and vertically printed rods were characterized using optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) coupled with energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). A typical microstructure of the alloy consists of primary-α and vanadium-enriched β phases. Compared to the horizontal samples, vertically print...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: Available online 11 November 2019Source: Materials Science and Engineering: AAuthor(s): Lei Dai, Zhong Liu, Liming Yu, Yongchang Liu, Zengmin ShiAbstractFe–9Cr ODS alloys elaborated by mechanical milling (MM) and followed by hot isostatic pressing (HIP) and hot rolling (HR) have been studied using transmission electron microscopy (TEM) and atom probe tomography (APT) to understand their microstructural characterization. The as-HIP alloy exhibited equiaxed ferrite and contained nanoparticles and low density of dislocations. The as-HR alloy manifested elongated ferrite and contained nanoclusters and h...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
This study investigated microstructure formation as a function of orientation-dependent surface tension anisotropy during directional solidification of Al-4.5%Cu alloy. Axial dendrites (AD), tilted dendrite (TD), and degenerate pattern (DP) were identified in the solidified microstructures of the single crystals. A single-crystal specimen with a stable DP, which was characterized by successive splitting tips, was carefully prepared and specifically investigated. The corresponding mechanical properties were compared with those of single-crystal AD and TD specimens. The ductility and toughness of the single-crystal specimen ...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Hojjat Naji, Jafar Khalil-Allafi, Vida KhaliliAbstractThe present work was aimed to quantitatively analyze the phases in the Ni-rich NiTi shape memory alloy which was aged at different temperatures of 470, 500 and 530 °C for 11, 38, 196 and 536 h. The aging treatment was done while applying various stress values. The phase transformation behavior of prepared specimens was analyzed using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) at ambient temperature and 75 °C. The weight percent of the dif...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Materials Research and TechnologyAuthor(s): Michelle Souza Oliveira, Fabio da Costa Garcia Filho, Artur Camposo Pereira, Larissa Fernandes Nunes, Fernanda Santos da Luz, Fábio de Oliveira Braga, Henry Alonso Colorado, Sergio Neves MonteiroAbstractThe ballistic performance of multilayered armor system (MAS) with front ceramic tile, followed by a laminate of up to 50 vol.% of fique fabric-reinforced epoxy matrix and back by a 5062H34 aluminum alloy was evaluated. The backface signature (BFS) caused by the bullet in a block of clay witness behin...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Authors: İşeri Nepesov M, Dinleyici M, Kılıç Ö, Ceyhan M, Gürler N, Dinleyici EÇ Abstract Streptococcus pneumoniae is a major cause of bacterial meningitis in children. It can progress and carries a serious risk of mortality and morbidity despite effective treatment. Cochlear implantation is a fairly successful procedure for restoring hearing in cases of sensorineural hearing loss. Moreover, patients with cochlear implants are at increased risk of contracting pneumococcal meningitis compared to the general population. The development of meningitis is associated with pathogens in the midd...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
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Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 12 November 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Yingcui Bu, Huihui Zhang, Zhiheng Li, Aidong Wang, Junjun Wang, Xiaojiao Zhu, Jie Zhang, Weiju Zhu, Guangmei Chen, Hongping ZhouAbstractTraditional biotechnology, taking advantage of fluorescent protein (FP) to investigate the foreign protein, was difficult to visualize and image accurately in living cells. Herein, bovine serum albumin (BSA) was illumined in virtue of the prepared probe 1, which could monitor the foreign protein of the intracellular recognition, transportation and metabolism under confocal microscopy. Ver...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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