LB1483 Preferential development of nodular basal cell carcinomas from Lgr6+ cells in skin

Uncontrolled Hedgehog (Hh) signaling underlies the development of basal cell carcinoma (BCC), with superficial BCCs arising from interfollicular epidermis and nodular tumors from hair follicle epithelia. However, the precise cell populations that give rise to different BCC subtypes have not been fully defined. Moreover, although genetic or pharmacological shut-down of oncogenic Hh signaling in BCC leaves behind a small population of dormant tumor cells, the long-term fate of these cells has not been investigated.

Source: Journal of Investigative Dermatology - August 21, 2018 Category: Dermatology Authors: M. Grachtchouk, D. Wilbert, A. Hoover, A. Dlugosz Tags: Carcinogenesis and Cancer Genetics Source Type: research