LB1529 Repeated exposure to hard water and surfactant impairs epidermal barrier development in vitro

The development and organization of human skin barrier function after birth is a delicate adaptive process leading to a mature stratum corneum (SC) at the end of infancy. Before SC complete formation, skin is considered as immature and clinical data have demonstrated its fragility and sensitivity towards the domestic water hardness increasing the atopic dermatitis risk due to surfactants deposition. An experimental in vitro model recapitulating immature skin features has been developed based on a Reconstructed Human Epidermis (RHE) used at early stage of differentiation (day 12).

Source: Journal of Investigative Dermatology - August 21, 2018 Category: Dermatology Authors: J. Bourland, F. Ranzini, A. Semenzato, G. Baratto, M. Meloni Tags: Epidermal Structure and Barrier Function Source Type: research