LB1551 How to balance the adjuvanticity and cytotoxicity of polyethylenimine as melanoma vaccines

Immunotherapy is the indispensable part for melanoma. Polyethylenimine (PEI) is a kind of cationic polymer, which has shown great adjuvanticity in previous studies, possessing as both immunostimulant and antigen vehicle. However, its positive charge-related cytotoxicity limits its medical application. Here, we systematically quantified and balanced these two properties in a series of branched PEI. First, we found that only certain branched PEI has direct immunoactivation effects, and the cytotoxicity of proper intensity induced by branched PEI seems essential to its adjuvanticity.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research