The burden of overall and cause-specific respiratory morbidity due to ambient air pollution in Sichuan Basin, China: A multi-city time-series analysis.

This study aimed to estimate the short-term effects of ambient air pollutants (PM10, PM2.5, NO2 and SO2) on hospital admissions (HAs) for overall and cause-specific respiratory diseases, as well as the associated burden in 17 cities of Sichuan Basin, China during 2015-2016. Firstly, city-specific effect estimates for each pollutant on respiratory HAs were obtained using generalized additive model with quasi-Poisson link, and then random- or fixed-effects meta-analysis was applied to pool the effect estimates at the regional level. Subgroup analyses by sex, age, season and region were also performed. A total of 757,712 respiratory HAs were collected from all the tertiary and secondary hospitals located in the 17 cities. Risks of HAs for overall and cause-specific respiratory diseases were elevated following increased PM10, PM2.5, NO2 and SO2 exposure. An increase of 10 μg/m3 in PM10 at lag01, PM2.5 at lag01, NO2 at lag0 and SO2 at lag02 was associated with a 0.43% (95% CI: 0.33%, 0.53%), 0.53% (95% CI: 0.39%, 0.68%), 2.36% (95% CI: 1.75%, 2.98%) and 2.54% (95% CI: 1.51%, 3.59%) increases in total respiratory HAs, respectively. Children (≤ 14 years) and elderly (≥ 65 years) appeared to be more vulnerable to the effects of ambient air pollutants. Comparing to the WHO's air quality guidelines, we estimated that 1.84% (95%CI: 1.42%, 2.25%), 1.73% (95%CI: 1.27%, 2.19%) and 0.34% (95%CI: 0.21%, 0.48%) of respiratory HAs were due to PM10, PM2.5 and SO2 exposure, respectively. ...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research