Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats

Publication date: Available online 20 August 2018Source: Journal of Thermal BiologyAuthor(s): Sueli Ferreira da Fonseca, Vanessa Amaral Mendonça, Sara Barros Silva, Talita Emanuela Domingues, Dirceu Sousa Melo, Jeanne Brenda Martins, Washington Pires, Cynthia Ferreira Fernandes Santos, Wagner de Fátima Pereira, Laura Hora Rios Leite, Cândido Celso Coimbra, Hércules Ribeiro Leite, Ana Cristina Rodrigues LacerdaAbstractThere is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 μL of physostigmine (phy) or saline solution. Tail temperature (Ttail), internal body temperature (Tint), systolic arterial pressure (SAP), heart rate (HR) and metabolic rate were registered during 60 min while the animals remained at rest after randomly receiving the injections. The va...
Source: Journal of Thermal Biology - Category: Biology Source Type: research