Antimicrobial and toxicological behavior of montmorillonite immobilized metal nanoparticles

Publication date: 1 December 2018Source: Materials Science and Engineering: C, Volume 93Author(s): Anasuya Roy, Mangala Joshi, B.S. Butola, Sahil MalhotraAbstractWith increasing demand for novel and potent antimicrobial agents to combat cross-infections and infectious diseases, silver and copper based nanoparticles (NPs) deposited over supports such as montmorillonite (MMT) are playing a crucial role in shaping the current research scenario. Although materials based on Ag NP and Cu NP on MMT have been reported, its toxicological properties on human cell lines have not been accounted for. This paper reports a comparative study on synthesis, antibacterial, antifungal and toxicological behavior of Ag and Cu NPs deposited over MMT nanosheets synthesized by employment of different reduction media. The effect of synthesized NP-MMT hybrids on human erythrocytes and fibroblast cells has been evaluated. The NP formation was facilitated using borohydride and ethyl alcohol (wet chemical route) and photo-reduction and thermal treatment (physical reduction route). The NP-MMT hybrids showed NP formation over supporting silicate layers with particle size ~10–50 nm confirmed by TEM micrographs and loading of ~6–22 wt% of metallic element by EDX analysis. The MMT layers were peeled apart to accommodate NPs inside its galleries, confirmed by increased d-value in powder WAXD. The NP-hybrids showed excellent inhibition zone against bacteria E.coli and S. aureus and fungi A. niger. RBC he...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research