In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients

CONCLUSIONS Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Abstract Repurposing of currently approved medications is an attractive option for development of novel treatment strategies against physiological and infectious diseases. The anti-diabetic sulfonylurea glyburide has demonstrated off-target capacity to inhibit activation of the NLRP3 inflammasome in a variety of disease models, including vaginal candidiasis caused primarily by the fungal pathogen Candida albicans Therefore, we sought to determine which of the currently approved sulfonylurea drugs prevent release of IL-1β, a major inflammasome effector, during C. albicans challenge of the human macrophage-like...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
AbstractCandiduria is commonly seen in hospitalized patients and most of the patients are asymptomatic, but it may be due to cystitis, pyelonephritis, prostatitis, epididymo-orchitis or disseminated candidiasis. Major risk factors are diabetes mellitus, indwelling urinary catheters, use of broad-spectrum antibiotics, urinary obstruction, and admission to intensive care units.Candida urinary tract infections can be caused by hematogenous spread following candidemia, or retrograde route via the urethra. The presence ofCandida species in urine in asymptomatic patients does not warrant antifungal therapy except neutropenic pat...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Conclusions: High prevalence of fluconazole resistance is a potential cause of concern, and the rational use of this drug is important in the community. The above results could have an impact on public health, as fluconazole is one of the safest and effective oral antifungal agents available. The spread of resistance could have implications for its use in other situations including systemic fungal infections.
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Authors: DENTAL SUPPLEMENT, Contaldo M, Romano A, Mascitti M, Fiori F, Della Vella F, Serpico R, Santarelli A Abstract Candida species are commensal yeasts of the oral cavity, which, under predisposing systemic and/or local circumstances, are responsible for a wide variety of clinical manifestations, globally known as oral candidiasis. Candida-associated denture stomatitis is an oral candidiasis particularly affecting the oral mucosa covered by a dental prosthesis, with several degree of severity. Diabetics suffer oral candidiasis more frequently than healthy individuals do and if they are denture wearers, the risk...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
AbstractTo identify the prevalence ofC. albicans in primary endodontic infections of type two diabetes mellitus (T2DM) patients and compare their clinical and radiographical characteristics with a non-diabetic control group, establishing the possible relationship between primary endodontic infection, T2DM, andC. albicans, since diabetes mellitus (DM), influences the development, course, and response to the treatment of apical periodontitis, but the presence ofCandida albicans (C. albicans) has not been considered before. A total of 120 patients were selected and divided into two groups: 60 T2DM diagnosed patients and 60 no...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
CONCLUSIONS: A high index of suspicion for IFG should exist for patients with an immunocompromised status and diabetic patients with rhinocerebral mass lesions. Early diagnosis, aggressive surgical decompression, and a course of promptly initiated antifungal therapy are associated with a better prognosis. PMID: 31370017 [PubMed - in process]
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Publication date: Available online 25 July 2019Source: Food Research InternationalAuthor(s): Aylin W. Sahin, Emanuele Zannini, Aidan Coffey, Elke K. ArendtAbstractThe world is facing a big problem of non-communicable diseases, such as obesity, cardiovascular disease and diabetes. An excessive sugar consumption is considered as a main factor, which triggers these diseases. The two main sources of sugar in processed products on the market are sugar-sweetened beverages and sweet bakery products. Sugar reduction is challenging, especially in baked goods, since it interacts significantly with all ingredients. These interactions...
Source: Food Research International - Category: Food Science Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Abstract Aims: Oral candidiasis is a major oral manifestation of uncontrolled diabetes mellitus, and a number of cofactors are associated with the pathogenesis of this infection. Here, we describe the prevalence of oral Candida in a Sri Lankan cohort of type 2 diabetes mellitus and risk factors that predispose them to this common fungal infection. Methods: A case-control study was conducted in 250 diabetics with type 2 diabetes and 81 nondiabetic controls. Clinical and demographic data were collected using an interviewer administered questionnaire, and patient records. Oral rinse samples were collected to determin...
Source: Acta Odontologica Scandinavica - Category: Dentistry Authors: Tags: Acta Odontol Scand Source Type: research
Candidiasis in women of child-bearing age is a major problem in most hospitals in Nigeria. High vaginal swabs were analyzed for Candida presence in women of child bearing age using Chromogenic agar. Isolated Candida spp. were analyzed phylogenetically to trace their evolutionary relatedness. Growth rate assay was done using Sabouruand and Dextrose medium supplemented with NaCl and glucose. T...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
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