First report of an acute, obstructive thrombosis of a Melody® valve used for transcatheter pulmonary replacement

Publication date: Available online 20 August 2018Source: Canadian Journal of CardiologyAuthor(s): Joerg Kellermair, Roland Gitter, Rudolf Mair, Matthias Sigler, Michael Grund, Clemens SteinwenderAbstractTranscatheter pulmonary valve (TPV) replacement is an effective therapy of right ventricular outflow tract (RVOT) conduit dysfunction. Acute complications following TPV implantation include infective endocarditis, stent fracture and device dislocation. Herein, we present a novel, life-threatening complication: an acute, non-infectious TPV thrombosis.Within 24 hours after implantation of a Melody® system, our patient developed an acute TPV thrombosis characterized by severe TPV stenosis on echocardiography and contrast filling defects on computed-tomography pulmonary angiography images. Genetic testing revealed heterozygous prothrombin G20210A polymorphism and homozygous 4G/4G polymorphism of the plasminogen-activator-inhibitor (PAI-1). The patient recovered after surgical valve replacement with a pulmonary homograft.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research