Monocyte-derived dendritic cells reflect the immune functional status of a chromophobe renal cell carcinoma patient: Could it be a general phenomenon?

Conclusion The presence of a ChRCC affected Mo-DCs generated in vitro, which recovered their function after tumor removal. This indicates that the favorable outcome observed after ChRCC resection may be due to the restoration of immunocompetence. Furthermore, since functional alterations described for DCs within tumors may be also found in Mo-DCs, their accurate functional analysis—not restricted to the determination of their surface immunophenotype—may provide an indirect “window” to the tumor microenvironment.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research