Influence of eukaryotic translation initiation factor 6 on non –small cell lung cancer development and progression

Non –small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Dysregulation of protein synthesis plays a major role in carcinogenesis, a process regulated at multiple levels, including translation of mRNA into proteins. Ribosome assembly requires correct association of ri bosome subunits, which is ensured by eukaryotic translation initiation factors (eIFs). eIFs have become targets in cancer therapy studies, and promising data on eIF6 in various cancer entities have been reported.

Source: European Journal of Cancer - August 1, 2018 Category: Cancer & Oncology Authors: Nadine Gantenbein, Eva Bernhart, Ines Anders, Nicole Golob-Schwarzl, Stefanie Krassnig, Christina Wodlej, Luka Brcic, Joerg Lindenmann, Nicole Fink-Neuboeck, Franz Gollowitsch, Elvira Stacher-Priehse, Martin Asslaber, Margit Gogg-Kamerer, Jana Rolff, Jens Tags: Original Research Source Type: research