The notch pathway promotes NF- κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.

Conclusion: Notch1 modulates the NF-κB pathway through Asb2α, indicating that Asb2α inhibition is a promising option for targeted therapy against T-ALL.
PMID: 30116272 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - August 18, 2018 Category: Biochemistry Authors: Wu W, Nie L, Zhang L, Li Y Tags: Cell Mol Biol Lett Source Type: research