Characterization of pelvic and cervical microbiotas from patients with pelvic inflammatory disease.

CONCLUSION: The NGS-based method provides a more informative profile of pelvic microbiota than the culture method. The pelvic and cervical microbiota from the same patient were inconsistent with each other, and thus therapeutic decisions based on cervical microbiota may lead to antimicrobial misuse. PMID: 30113305 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Acinetobacter sp. is among the ESKAPE organisms which represent the major nosocomial pathogens that exhibited a high resistance rate. A. pittii, frequently associated with antimicrobial resistance particularly to carbapenems, is one of the most common Acinetobacter species causing invasive infection. Pandrug resistant A. pittii has rarely been reported. Here, we report the case of a patient with acute exacerbations of chronic obstructive pulmonary disease three years after double lung transplantation and developed severe pneumonia associated with pandrug resistant A. pittii infection. Phenotypic and genomic characteristics...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
AbstractThe purpose of this narrative review is to bring together the most recent epidemiologic, preclinical, and clinical findings to offer our perspective on best practices for managing patients withA.  baumannii infections with an emphasis on carbapenem-resistantA.  baumannii (CRAB). To date, the preferred treatment for CRAB infections has not been defined. Traditional agents with retained in vitro activity (aminoglycosides, polymyxins, and tetracyclines) are limited by suboptimal pharmacokinetic characteristics, emergence of resistance, and/or toxicity. Recently developed and US Food and Drug Administration (...
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Endolysin-based therapeutics are promising antibacterial agents and can successfully supplement the existing antibacterial drugs array. It is specifically important in the case of Gram-negative pathogens, e.g., ESKAPE group bacteria, which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, and are highly inclined to gain multiple antibiotic resistance. Despite numerous works devoted to the screening of new lytic enzymes and investigations of their biochemical properties, there are significant breaches in some aspects of the...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: It was emphasized that urine culture should be done in early antenatal visit as routine screening to identify ASB in pregnant females as it can prevent fetal and maternal complications.
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research
CONCLUSIONS: IMI/REL showed high activity against the strains that carry Klebsiella pneumoniae carbapenemase (KPC) and against carbapenem-resistant P. aeruginosa unrelated to the VIM enzyme, mainly AmpC beta lactamase associated with impermeability. Against strains carrying oxacillinase 48 (OXA-48) associated with extended-spectrum beta-lactamase (ESBL), IMI/REL presented activity only slightly better than IMI and had no beneficial effect superior to IMI against A. baumannii.PMID:34636220 | DOI:10.37201/req/102.2021
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Source Type: research
Curr Biol. 2021 Oct 11;31(19):R1120-R1122. doi: 10.1016/j.cub.2021.08.024.ABSTRACTMicrobial residents of floral nectar must survive in a carbohydrate-rich yet seemingly nitrogen-poor environment. A new study shows that Acinetobacter spp., common nectar-inhabiting bacteria, differentially induce the pollen commonly found in nectar to germinate and burst, releasing nutrients for microbial growth.PMID:34637711 | DOI:10.1016/j.cub.2021.08.024
Source: Current Biology - Category: Biology Authors: Source Type: research
CONCLUSIONS: IMI/REL showed high activity against the strains that carry Klebsiella pneumoniae carbapenemase (KPC) and against carbapenem-resistant P. aeruginosa unrelated to the VIM enzyme, mainly AmpC beta lactamase associated with impermeability. Against strains carrying oxacillinase 48 (OXA-48) associated with extended-spectrum beta-lactamase (ESBL), IMI/REL presented activity only slightly better than IMI and had no beneficial effect superior to IMI against A. baumannii.PMID:34636220 | DOI:10.37201/req/102.2021
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: Considering the increase of resistance to antiseptics, it is of importance to monitor the susceptibility of A. baumannii to antiseptics and to promote antiseptic stewardship in hospitals. Furthermore, in this study great diversity was observed among A. baumannii isolates, which is important in understanding the molecular epidemiology of the outbreaks caused by this organism in the hospitals.PMID:34635960 | DOI:10.1007/s11033-021-06758-3
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
Curr Biol. 2021 Oct 11;31(19):R1120-R1122. doi: 10.1016/j.cub.2021.08.024.ABSTRACTMicrobial residents of floral nectar must survive in a carbohydrate-rich yet seemingly nitrogen-poor environment. A new study shows that Acinetobacter spp., common nectar-inhabiting bacteria, differentially induce the pollen commonly found in nectar to germinate and burst, releasing nutrients for microbial growth.PMID:34637711 | DOI:10.1016/j.cub.2021.08.024
Source: Current Biology - Category: Biology Authors: Source Type: research
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